BDBM463295 4-(4-amino-2-{8-(3- fluorobenzyl)imidazo- [1,2-a]pyrazin-6-yl}-5- methyl-6-oxo-6,7- dihydro-5H-pyrrolo- [2,3-d]pyrimidin-5-yl)- 2-chloro-6-hydroxy- benzonitrile::US10780092, Example 144-A

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1cc(O)c(C#N)c(Cl)c1

InChI Key InChIKey=DBDDDFQYAYJALJ-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463295   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463295(4-(4-amino-2-{8-(3- fluorobenzyl)imidazo- [1,2-a]p...)
Affinity DataKi:  0.333nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
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Date in BDB:
5/2/2021
Entry Details
US Patent