BDBM463769 US10781209, Example 9B::US11059821, Example 9B::US11702416, Example 9B

SMILES COc1cc2c(c(-c3cn(C)c(=O)c4[nH]ccc34)c1)O[C@H](C(C)C)C(=O)N2

InChI Key InChIKey=KRJWGRKYQVYBNX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 463769   

TargetBromodomain-containing protein 4 [42-168](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 463769BDBM463769(US10781209, Example 9B | US11059821, Example 9B | ...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 463769BDBM463769(US10781209, Example 9B | US11059821, Example 9B | ...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 463769BDBM463769(US10781209, Example 9B | US11059821, Example 9B | ...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 463769BDBM463769(US10781209, Example 9B | US11059821, Example 9B | ...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 463769BDBM463769(US10781209, Example 9B | US11059821, Example 9B | ...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 463769BDBM463769(US10781209, Example 9B | US11059821, Example 9B | ...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhibitors were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetBromodomain-containing protein 4 [44-167](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 463769BDBM463769(US10781209, Example 9B | US11059821, Example 9B | ...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 463769BDBM463769(US10781209, Example 9B | US11059821, Example 9B | ...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhibitors were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent