BDBM464325 3-(6-ethyl-5-(1H- pyrazol-4-yl)pyridin- 2-yl)-1-(3- methoxybenzyl)-8- (tetrahydrofuran-2- carbonyl)-1,3,8- triazaspiro[4.5]decan- 2-one::US10787450, Example 207

SMILES CCc1nc(N2CC3(CCN(C(=O)C4CCCO4)CC3)N(Cc3cccc(OC)c3)C2=O)ccc1-c1cn[nH]c1

InChI Key InChIKey=MKUKTOBOZNPJPW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464325   

TargetRho-associated protein kinase 2(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 464325BDBM464325(3-(6-ethyl-5-(1H- pyrazol-4-yl)pyridin- 2-yl)-1-(3...)
Affinity DataIC50: 3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
US Patent