BDBM466410 N-[(3- cyanophenyl) methyl]-5-(7H- pyrrolo[2,3- d]pyrimidin-4-yl)- 5-azaspiro [2.5]octane- 8-carboxamide::US10799507, Example 70

SMILES O=C(NCc1cccc(c1)C#N)C1CCN(CC11CC1)c1ncnc2[nH]ccc12

InChI Key InChIKey=YRXBYQWKGSSZAH-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 466410   

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandPNGBDBM466410(N-[(3- cyanophenyl) methyl]-5-(7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  5.5nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM466410(N-[(3- cyanophenyl) methyl]-5-(7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  8.60nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

US Patent
LigandPNGBDBM466410(N-[(3- cyanophenyl) methyl]-5-(7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  32.6nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent