BDBM466460 N-[(1R)-1-(3- cyano-4-fluoro- phenyl)ethyl]-5- (7H-pyrrolo[2,3- d]pyrimidin-4-yl)- 5-azaspiro [2.5]octane- 8-carboxamide::US10799507, Example 123

SMILES C[C@@H](NC(=O)C1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)c(c1)C#N

InChI Key InChIKey=JHICKMUDKJNZBU-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 466460   

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandPNGBDBM466460(N-[(1R)-1-(3- cyano-4-fluoro- phenyl)ethyl]-5- (7H...)
Affinity DataEC50:  16.3nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM466460(N-[(1R)-1-(3- cyano-4-fluoro- phenyl)ethyl]-5- (7H...)
Affinity DataEC50:  21.4nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

US Patent
LigandPNGBDBM466460(N-[(1R)-1-(3- cyano-4-fluoro- phenyl)ethyl]-5- (7H...)
Affinity DataEC50:  63.9nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent