BDBM466595 US10800757, Compound 11::US10889568, Compound 11::[4-(6-Amino-5-methoxy-pyridazin-3- yl)-piperidin-1-yl]-[5-(4-fluoro- phenoxy)-4-methoxy-pyridin-2-yl]- methanone

SMILES COc1cc(nnc1N)C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccc(F)cc2)cn1

InChI Key InChIKey=RRMIIYGCJYBWKP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 466595   

TargetShort transient receptor potential channel 6(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM466595(US10889568, Compound 11 | [4-(6-Amino-5-methoxy-py...)
Affinity DataIC50: 27nMAssay Description:This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetShort transient receptor potential channel 6(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM466595(US10889568, Compound 11 | [4-(6-Amino-5-methoxy-py...)
Affinity DataIC50: 27nMAssay Description:The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent