BDBM466682 US10800761, Example 1::US11731958, Example 1

SMILES COc1cccc(F)c1-c1nccc(n1)C(=O)Nc1cc(F)ccc1N1C[C@H]2C[C@@H]1CN2

InChI Key InChIKey=JKHBVOCOHYSWTQ-HUUCEWRRSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 466682   

LigandPNGBDBM466682(US10800761, Example 1 | US11731958, Example 1)
Affinity DataKi:  2.20nMAssay Description:In vitro inhibition of human carbonic anhydrase II (0.1 nM).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM466682(US10800761, Example 1 | US11731958, Example 1)
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466682(US10800761, Example 1 | US11731958, Example 1)
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466682(US10800761, Example 1 | US11731958, Example 1)
Affinity DataKi:  541nMAssay Description:Inhibitory activity against human carbonic anhydrase II using pH stat assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM466682(US10800761, Example 1 | US11731958, Example 1)
Affinity DataIC50:  94nMAssay Description:Compound was evaluated for the inhibition of Escherichia coli Thymidylate SynthaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM466682(US10800761, Example 1 | US11731958, Example 1)
Affinity DataIC50:  104nMAssay Description:Histamine H2 receptor antagonism on the right atrium of the guinea pigMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM466682(US10800761, Example 1 | US11731958, Example 1)
Affinity DataIC50:  1.69E+3nMAssay Description:The compound was tested for alpha-adrenergic activity against Alpha-1 adrenergic receptor from rat aorta.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed