BDBM466903 US10800769, Example 6::methyl tetrahydropyran- 4-yl ({6-[(3R)-3-methyl- morpholin-4-yl]-2-{1H- pyrrolo[2,3-b]pyridin-4- yl}pyrimidin-4-yl}- imino)-lambda6-sulfanone

SMILES C[C@@H]1COCCN1c1cc(N=S(C)(=O)C2CCOCC2)nc(n1)-c1ccnc2[nH]ccc12

InChI Key InChIKey=YQUDFCUTBNDZAV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 466903   

TargetSerine/threonine-protein kinase ATR(Human)
The University of Texas MD Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 466903BDBM466903(methyl tetrahydropyran- 4-yl ({6-[(3R)-3-methyl- m...)
Affinity DataIC50: 17nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 466903BDBM466903(methyl tetrahydropyran- 4-yl ({6-[(3R)-3-methyl- m...)
Affinity DataIC50: 212nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
The University of Texas MD Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 466903BDBM466903(methyl tetrahydropyran- 4-yl ({6-[(3R)-3-methyl- m...)
Affinity DataIC50: 213nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
The University of Texas MD Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 466903BDBM466903(methyl tetrahydropyran- 4-yl ({6-[(3R)-3-methyl- m...)
Affinity DataIC50: 6.36E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed