BDBM466948 Methyl 4-(3-((2,2-difluorocyclopropyl) methyl)-[1,2,4]triazolo[4,3-a] pyridin-7-yl)-3-fluorobenzonate::US10800776, Example 29

SMILES COC(=O)c1ccc(c(F)c1)-c1ccn2c(CC3CC3(F)F)nnc2c1

InChI Key InChIKey=VMAMSACVMZULQC-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 466948   

TargetMetabotropic glutamate receptor 2(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM466948(Methyl 4-(3-((2,2-difluorocyclopropyl) methyl)-[1,...)
Affinity DataEC50:  541nMAssay Description:Experimental materials: HEK/mGluR2 cell line (human GluR2 transfected HEK cell line), DMEM (FBS) medium, positive control LY487379 (purchased from si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM466948(Methyl 4-(3-((2,2-difluorocyclopropyl) methyl)-[1,...)
Affinity DataIC50: 1.73E+4nMAssay Description:Experimental method: hERG patch clamp detection methodExperimental procedure: Compound preparation: the stock solution of a compound was diluted with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent