BDBM466955 8-chloro-3-((2,2-difluorocyclopropyl) methyl)-7-(4-fluoro-2-methylphenyl)- [1,2,4]triazole[4,3-a]pyridine::US10800776, Example 41

SMILES Cc1cc(F)ccc1-c1ccn2c(CC3CC3(F)F)nnc2c1Cl

InChI Key InChIKey=UQNYQQKYHAYDBS-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 466955   

TargetMetabotropic glutamate receptor 2(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM466955(8-chloro-3-((2,2-difluorocyclopropyl) methyl)-7-(4...)
Affinity DataEC50:  856nMAssay Description:Experimental materials: HEK/mGluR2 cell line (human GluR2 transfected HEK cell line), DMEM (FBS) medium, positive control LY487379 (purchased from si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM466955(8-chloro-3-((2,2-difluorocyclopropyl) methyl)-7-(4...)
Affinity DataIC50: 1.12E+4nMAssay Description:Experimental method: hERG patch clamp detection methodExperimental procedure: Compound preparation: the stock solution of a compound was diluted with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent