BDBM467011 (-)-6-fluoro-8-[(1R*,2R*)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one::US10800783, Example 6::US11396512, Example 6

SMILES C[C@@]1(O)CCC[C@H]1n1c2nc(NC3CCN(CC3)S(C)(=O)=O)ncc2cc(F)c1=O

InChI Key InChIKey=GCZKEPXNHVTKDQ-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 467011   

LigandPNGBDBM467011((-)-6-fluoro-8-[(1R*,2R*)-2-hydroxy-2-methylcyclop...)
Affinity DataKi:  0.480nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
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LigandPNGBDBM467011((-)-6-fluoro-8-[(1R*,2R*)-2-hydroxy-2-methylcyclop...)
Affinity DataKi:  0.480nMAssay Description:The mobility shift assay electrophoretically separates the fluorescently labeled peptides (substrate and phosphorylated product) following the kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
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LigandPNGBDBM467011((-)-6-fluoro-8-[(1R*,2R*)-2-hydroxy-2-methylcyclop...)
Affinity DataKi:  2.38nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

LigandPNGBDBM467011((-)-6-fluoro-8-[(1R*,2R*)-2-hydroxy-2-methylcyclop...)
Affinity DataKi:  2.38nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent

LigandPNGBDBM467011((-)-6-fluoro-8-[(1R*,2R*)-2-hydroxy-2-methylcyclop...)
Affinity DataKi:  3.94nMAssay Description:The purpose CDK4/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

LigandPNGBDBM467011((-)-6-fluoro-8-[(1R*,2R*)-2-hydroxy-2-methylcyclop...)
Affinity DataKi:  3.94nMAssay Description:The purpose CDK4/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent

LigandPNGBDBM467011((-)-6-fluoro-8-[(1R*,2R*)-2-hydroxy-2-methylcyclop...)
Affinity DataKi:  4.75nMAssay Description:The mobility shift assay electrophoretically separates the fluorescently labeled peptides (substrate and phosphorylated product) following the kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
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LigandPNGBDBM467011((-)-6-fluoro-8-[(1R*,2R*)-2-hydroxy-2-methylcyclop...)
Affinity DataKi:  13.1nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent