BDBM468958 1-[2-[(3R,5S,6R)-5-Amino- 6-(2,5- difluorophenyl)tetrahydro- pyran-3-yl]isoindolin-5-yl]-N- [(2,3- difluorophenyl)methyl]-3- hydroxy-2-oxo-pyrrolidine- 3-carboxamide, iosmer 1 hydrochloride::US10807971, Example 2
SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1Cc2ccc(cc2C1)N1CCC(O)(C(=O)NCc2cccc(F)c2F)C1=O
InChI Key InChIKey=MQOWMDPWQJBNJZ-ZJXHWGHKSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 468958
Affinity DataIC50: 3.67nMAssay Description:Human DPP-4 ((39-766)-His) and mouse DPP-4 ((29-760)-His) are purified by gel chromatography for use in the assay. The final concentration of hDPP-4 ...More data for this Ligand-Target Pair
Affinity DataIC50: 33.6nMAssay Description:The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...More data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...More data for this Ligand-Target Pair
Affinity DataIC50: 6.46nMAssay Description:Human DPP-4 ((39-766)-His) and mouse DPP-4 ((29-760)-His) are purified by gel chromatography for use in the assay. The final concentration of hDPP-4 ...More data for this Ligand-Target Pair