BDBM468981 (3S)-1-[2-[1-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)tetrahydropyran-3-yl]-3,6-dihydro-2H-pyridin-4-yl]pyrimidin-5-yl]-N-[(3-chloro-5-fluoro-phenyl)methyl]-3-hydroxy-2-oxo-pyrrolidine-3-carboxamide, hydrochloride::US10807971, Example 17
SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1CCC(=CC1)c1ncc(cn1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
InChI Key InChIKey=WDNVNCPECUHEGM-DODPDUHYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 468981
Affinity DataIC50: 14.7nMAssay Description:Human DPP-4 ((39-766)-His) and mouse DPP-4 ((29-760)-His) are purified by gel chromatography for use in the assay. The final concentration of hDPP-4 ...More data for this Ligand-Target Pair
Affinity DataIC50: 283nMAssay Description:The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...More data for this Ligand-Target Pair
Affinity DataIC50: 25.5nMAssay Description:Human DPP-4 ((39-766)-His) and mouse DPP-4 ((29-760)-His) are purified by gel chromatography for use in the assay. The final concentration of hDPP-4 ...More data for this Ligand-Target Pair