BDBM470810 (1S,3'R,6'R,7'S,8'E,11'S,12'R)- 6-chloro-7'-methoxy-11',12'- dimethyl-7'-((9aR)-octahydro- 2H-pyrido[1,2-a]pyrazin-2- ylmethyl)-3,4-dihydro- 2H,15'H-spiro[naphthalene- 1,22'-[20]oxa[13]thia[1,14] diazatetracyclo [14.7.2.0~3,6~.0~19,24~] pentacosa[8,16,18,24]tetraen]- 15'-one 13',13'-dioxide::US10821115, Example 197::US11224601, Example 197
SMILES CO[C@@]1(CN2CCN3CCCC[C@@H]3C2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2
InChI Key InChIKey=BJTFTQIBRVBSBH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 470810
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 0.0150nMAssay Description:Binding affinity to MCL-1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataKi: 0.0150nMAssay Description:Binding affinity to MCL-1 (unknown origin) assessed as inhibition constant by TR-FRET assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Human)
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: 0.364nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Affinity DataIC50: 0.364nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair