BDBM471594 US10822334, Compound 6

SMILES COc1cc(O[C@H]2CCN(C)CC2(F)F)c2c(Nc3ccc(Oc4ccn5ncnc5c4)c(C)c3)ncnc2c1

InChI Key InChIKey=IDQNCHCNBVCUHC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 471594   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 471594BDBM471594(US10822334, Compound 6)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of hypoxia induced HIF1 transcriptional activity in human Hep3B cells by cell-based HRE reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 471594BDBM471594(US10822334, Compound 6)
Affinity DataIC50: 19.6nMAssay Description:HER2: The compounds' inhibition of target modulation were determined as follows: BT474 cells were sorted in 96 well plates (20000 cells/well) wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 471594BDBM471594(US10822334, Compound 6)
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells by cell based reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 471594BDBM471594(US10822334, Compound 6)
Affinity DataIC50: 3.29E+3nMAssay Description:EGFR: The compounds' inhibition of target modulation were determined as follows: NCI-H838 cells were sorted in 96 well plates (20000 cells/well) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
US Patent