BDBM471617 US10822334, Compound ONT380::US20230382923, Compound Tucatinib
SMILES Cc1cc(Nc2ncnc3ccc(NC4=NC(C)(C)CO4)cc23)ccc1Oc1ccn2ncnc2c1
InChI Key InChIKey=SDEAXTCZPQIFQM-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 471617
Affinity DataIC50: 2nMAssay Description:HER2: The compounds' inhibition of target modulation were determined as follows: BT474 cells were sorted in 96 well plates (20000 cells/well) wit...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+3nMAssay Description:EGFR: The compounds' inhibition of target modulation were determined as follows: NCI-H838 cells were sorted in 96 well plates (20000 cells/well) ...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated ERBB2 levels. A capture antibody able to detect phosphorylated an...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:1) 1× kinase reaction buffer was prepared from 1 volume of 5× kinase reaction buffer and 4 volumes of water, 1 mM dithiothreitol, 5 mM magnesium chlo...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 449nMAssay Description:Inhibition of N-terminal GST fused EGFR (668 to 1091 residues) (unknown origin) using poly (Glu-Tyr) E4Y1 peptide as substrate incubated for 2 hrs by...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Table B3: Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated ERBB2 levels. A capture antibody able to detect phospho...More data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 449nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Inhibition of N-terminal GST fused HER2 (679 to 1255 residues) (unknown origin) using poly (Glu-Tyr) E4Y1 peptide as substrate measured after 4 hrs b...More data for this Ligand-Target Pair