BDBM47182 US8604206, (3R,4R,5S)-5-((R)-1-fluoropropyl)-piperidine-3,4-diol hydrochloride

SMILES CC[C@@H](F)C1CNC[C@@H](O)[C@@H]1O

InChI Key InChIKey=JJOAXUOFRVBCHL-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 47182   

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM47182(US8604206, (3R,4R,5S)-5-((R)-1-fluoropropyl)-piper...)
Affinity DataKi:  31nM IC50: 60nMAssay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM47182(US8604206, (3R,4R,5S)-5-((R)-1-fluoropropyl)-piper...)
Affinity DataKi:  121nM IC50: 291nMAssay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent