BDBM471933 5-[3-[(3S)-4-(4- chloro-3,5- dimethoxy- phenyl)- 3-methyl- piperazin- 1-yl]-2-methyl-3- oxo-propyl]-5- methyl- imidazolidine- 2,4-dione::US10829478, Compound 44

SMILES COc1cc(cc(OC)c1Cl)N1CCN(C[C@@H]1C)C(=O)[C@@H](C)C[C@@]1(C)NC(=O)NC1=O

InChI Key InChIKey=LCPBZVLPMNYZLU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 471933   

LigandPNGBDBM471933(5-[3-[(3S)-4-(4- chloro-3,5- dimethoxy- phenyl)- 3...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM471933(5-[3-[(3S)-4-(4- chloro-3,5- dimethoxy- phenyl)- 3...)
Affinity DataIC50: 75nMAssay Description:TABLE IX: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent