BDBM472674 10,10-dimethyl-2-((5-(4- methylpiperazin-1-yl)pyridin-2- yl)amino)-6,6a,9,10-tetrahydro- 5H-pyrazino[1',2':1,6]pyrido[2,3- d]pyrimidin-7(8H)-one::US10829490, Cmpd # 2

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CCC4N(c3n2)C(C)(C)CNC4=O)nc1

InChI Key InChIKey=XBBXTMOEBQDBHN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 472674   

TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
Gi Therapeutics

US Patent
LigandPNGBDBM472674(10,10-dimethyl-2-((5-(4- methylpiperazin-1-yl)pyri...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Gi Therapeutics

US Patent
LigandPNGBDBM472674(10,10-dimethyl-2-((5-(4- methylpiperazin-1-yl)pyri...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Gi Therapeutics

US Patent
LigandPNGBDBM472674(10,10-dimethyl-2-((5-(4- methylpiperazin-1-yl)pyri...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetCyclin-dependent kinase 5 activator 1(Human)
Gi Therapeutics

US Patent
LigandPNGBDBM472674(10,10-dimethyl-2-((5-(4- methylpiperazin-1-yl)pyri...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C](Human)
Gi Therapeutics

US Patent
LigandPNGBDBM472674(10,10-dimethyl-2-((5-(4- methylpiperazin-1-yl)pyri...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Gi Therapeutics

US Patent
LigandPNGBDBM472674(10,10-dimethyl-2-((5-(4- methylpiperazin-1-yl)pyri...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Gi Therapeutics

US Patent
LigandPNGBDBM472674(10,10-dimethyl-2-((5-(4- methylpiperazin-1-yl)pyri...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent