BDBM472693 (R)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitrophenyl)sulfonyl)-2-((1H-pyrrolo[2,3-b] pyridin-5-yl)oxy)-4-(4-((6-(4- chlorophenyl)spiro[3.5]non-6-en-7- yl)methyl)piperazin-1-yl)benzamide::US10829488, Cpd. No. 13::US11718613, Compound 13

SMILES O=C(NS(=O)(=O)c1ccc(NC[C@@H]2COCCO2)c([N+](=O)[O-])c1)c1ccc(N2CCN(CC3=C(c4ccc(Cl)cc4)CC4(CCC4)CC3)CC2)cc1Oc1cnc2[nH]ccc2c1

InChI Key InChIKey=FNBXDBIYRAPDPI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 472693   

TargetApoptosis regulator Bcl-2(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 472693BDBM472693((R)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 1.30nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetBcl-2-like protein 11 [72-87](Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 472693BDBM472693((R)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 1.30nMAssay Description:Bcl-2 and Bcl-xL Inhibition: Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2021
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 472693BDBM472693((R)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 2.40nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 472693BDBM472693((R)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 6.40nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetBcl-2-like protein 11 [81-106](Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 472693BDBM472693((R)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 14.8nMAssay Description:Bcl-2 and Bcl-xL Inhibition: Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2021
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 472693BDBM472693((R)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 14.8nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 472693BDBM472693((R)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 5.00E+3nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent