BDBM472725 2-(2,5-difluorophenyl)-4,4-difluoropyrrolidine ::US10829492, Example 4

SMILES NC(=O)c1c(N)nn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F

InChI Key InChIKey=LOHSQDXMJAKLOV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 472725   

TargetHigh affinity nerve growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472725(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidine | ...)
Affinity DataIC50: 1nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472725(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidine | ...)
Affinity DataIC50: 1nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472725(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidine | ...)
Affinity DataIC50: 10nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472725(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidine | ...)
Affinity DataIC50: 10nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472725(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidine | ...)
Affinity DataIC50: 2.00E+3nMAssay Description:JAK2: A testing platform for JAK2 kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent