BDBM473564 US10844057, Example 7::US10947229, Example 1::US11634419, Example 1::US11702415, Compound 1

SMILES CCc1cc(O)ccc1-c1ccc2c(-c3nc4c([nH]3)CN(C(C)C)[C@H](C(=O)N3CC(N(C)C)C3)C4)n[nH]c2c1

InChI Key InChIKey=VQIIUJSNIKEMCK-UHFFFAOYSA-N

Data  15 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 473564   

TargetTyrosine-protein kinase JAK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.0320nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetTyrosine-protein kinase JAK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.0320nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/26/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetTyrosine-protein kinase JAK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.0320nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/2/2023
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetTyrosine-protein kinase JAK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.0320nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/6/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetTyrosine-protein kinase JAK1(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.0630nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetTyrosine-protein kinase JAK3(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.0630nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/26/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetTyrosine-protein kinase JAK1(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.0630nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/26/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetTyrosine-protein kinase JAK3(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.0630nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetTyrosine-protein kinase JAK3(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.0630nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/2/2023
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetTyrosine-protein kinase JAK1(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.0630nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/2/2023
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetTyrosine-protein kinase JAK3(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.0630nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/6/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetTyrosine-protein kinase JAK1(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.0630nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/6/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.794nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/26/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.794nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataKi:  0.794nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/2/2023
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM473564(US10844057, Example 7 | US10947229, Example 1 | US...)Copy SMILESCopy InChI

Affinity DataIC50: 2.51nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/6/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL