BDBM473670 5-(1H-Indol-2-yl)-7-(propan-2- yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine::US10844067, Example 13::US11661423, Example 13

SMILES CC(C)c1cc(-c2cc3ccccc3[nH]2)c2c(N)ncnn12

InChI Key InChIKey=FIXAGEFQPAXDEP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 473670   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473670(5-(1H-Indol-2-yl)-7-(propan-2- yl)pyrrolo[2,1-f][1...)
Affinity DataIC50: 8.60nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473670(5-(1H-Indol-2-yl)-7-(propan-2- yl)pyrrolo[2,1-f][1...)
Affinity DataIC50: 8.60nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473670(5-(1H-Indol-2-yl)-7-(propan-2- yl)pyrrolo[2,1-f][1...)
Affinity DataIC50: 3.00E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473670(5-(1H-Indol-2-yl)-7-(propan-2- yl)pyrrolo[2,1-f][1...)
Affinity DataIC50: 3.00E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473670(5-(1H-Indol-2-yl)-7-(propan-2- yl)pyrrolo[2,1-f][1...)
Affinity DataIC50: 3.00E+3nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473670(5-(1H-Indol-2-yl)-7-(propan-2- yl)pyrrolo[2,1-f][1...)
Affinity DataIC50: 3.00E+3nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent