BDBM473702 5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isopropyl-pyrrolo[2,3-d]pyrimidin-4- amine::US10844067, Example 45::US11661423, Example 45

SMILES CC(C)n1cc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12

InChI Key InChIKey=XVIXQCFZHSLBTO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 473702   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473702(5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isop...)
Affinity DataIC50:  1.10nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473702(5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isop...)
Affinity DataIC50:  1.52E+3nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473702(5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isop...)
Affinity DataIC50:  26.1nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473702(5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isop...)
Affinity DataIC50:  1.10nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473702(5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isop...)
Affinity DataIC50:  1.52E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473702(5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isop...)
Affinity DataIC50:  26.1nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent