BDBM473718 3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4- d]pyrimidin-4-amine::US10844067, Example 61::US11661423, Example 61

SMILES Nc1ncnc2n(CC(F)(F)F)nc(-c3[nH]c4ncccc4c3Cl)c12

InChI Key InChIKey=HRMDYAOZPDKTPO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 473718   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473718(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-(2,2...)
Affinity DataIC50: 8nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473718(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-(2,2...)
Affinity DataIC50: 8nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473718(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-(2,2...)
Affinity DataIC50: 124nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473718(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-(2,2...)
Affinity DataIC50: 124nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473718(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-(2,2...)
Affinity DataIC50: 2.96E+4nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473718(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-(2,2...)
Affinity DataIC50: 2.96E+4nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
US Patent