BDBM473739 3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-propyl-1H-pyrazolo[3,4-d]pyrimidin-4- amine::US10844067, Example 82::US11661423, Example 82

SMILES CCCn1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12

InChI Key InChIKey=KUGYECJKTRGXSE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 473739   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473739(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-prop...)
Affinity DataIC50:  11.9nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473739(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-prop...)
Affinity DataIC50: >3.00E+4nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473739(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-prop...)
Affinity DataIC50:  95.1nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473739(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-prop...)
Affinity DataIC50:  11.9nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473739(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-prop...)
Affinity DataIC50: >3.00E+4nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473739(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-prop...)
Affinity DataIC50:  95.1nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent