BDBM473856 US10844069, Example 113

SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc4C(=O)CCCc4n(-c4cncc(F)c4)c3=O)cc2)c2c(N)nnnn12

InChI Key InChIKey=FKVIGBYWUWFCQP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 473856   

TargetTyrosine-protein kinase Mer(Human)
Incyte

US Patent
LigandPNGBDBM473856(US10844069, Example 113)
Affinity DataIC50: 5nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Incyte

US Patent
LigandPNGBDBM473856(US10844069, Example 113)
Affinity DataIC50: 5nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
Incyte

US Patent
LigandPNGBDBM473856(US10844069, Example 113)
Affinity DataIC50: 55nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent