BDBM474026 N-{5-[2-tert-Butyl-7-(methylsulfamoyl)-1-oxo-2,3-dihydro-1H-isoindol- 5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide::US10858355, Example 34

SMILES CNS(=O)(=O)c1cc(cc2CN(C(=O)c12)C(C)(C)C)-c1sc(NC(C)=O)nc1C

InChI Key InChIKey=AVEWTLONLKQIEU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 474026   

LigandPNGBDBM474026(N-{5-[2-tert-Butyl-7-(methylsulfamoyl)-1-oxo-2,3-d...)
Affinity DataIC50: 1.58nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent