BDBM474105 US10858364, formula (I)
SMILES CC#CC(=O)NCCCC(=O)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
InChI Key InChIKey=XZAATUBTUPPERZ-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 474105
Affinity DataIC50: 5nMAssay Description:TBDBTK enzyme (His-BTK (Millipore catalog #14-552)), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 ...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair
Affinity DataIC50: 343nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair
Affinity DataIC50: 345nMAssay Description:TEC enzyme (LifeTech # PV3269) and Eu-anti-HIS antibody (Invitrogen # PV5596) are mixed and diluted in kinase buffer (50 mM Hepes pH 7.5+10 mM MgCl2+...More data for this Ligand-Target Pair
Affinity DataIC50: 552nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair
Affinity DataIC50: 567nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.17E+3nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:TBITK enzyme (Millipore #14-660M) is diluted to 0.2 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.1% NaN3, 1 mM DTT, 2 mM MnCl2, ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair