BDBM474146 7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 2::US10858362, Example 35, isomer 2::US10912773, Example 35-isomer-3::US11472810, Example 35, isomer 2

SMILES C[C@@H]1C[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O

InChI Key InChIKey=NSFYZWGFIIQKQP-IAQYHMDHSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 474146   

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  364nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  41nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  41nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  364nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  166nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  41nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  364nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  166nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  41nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  82nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  18nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  8nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  364nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  166nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM474146(7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropy...)
Affinity DataIC50:  166nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent