BDBM474159 6-methyl-3-(tetrahydro-2H-pyran- 4-yl)-7-(4- (trifluoromethoxy)benzyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 41::US10912773, Example 41::US11472810, Example 41

SMILES Cc1cn2c(ncc2c(=O)n1Cc1ccc(OC(F)(F)F)cc1)C1CCOCC1

InChI Key InChIKey=UNRQWEFTRALILW-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 474159   

LigandPNGBDBM474159(US10912773, Example 41 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM474159(US10912773, Example 41 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 18nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

LigandPNGBDBM474159(US10912773, Example 41 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 18nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
US Patent

LigandPNGBDBM474159(US10912773, Example 41 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 18nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

LigandPNGBDBM474159(US10912773, Example 41 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 27nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM474159(US10912773, Example 41 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 27nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

LigandPNGBDBM474159(US10912773, Example 41 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 27nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
US Patent

LigandPNGBDBM474159(US10912773, Example 41 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 27nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

LigandPNGBDBM474159(US10912773, Example 41 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 52nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM474159(US10912773, Example 41 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 52nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

LigandPNGBDBM474159(US10912773, Example 41 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 52nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
US Patent

LigandPNGBDBM474159(US10912773, Example 41 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 52nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent