BDBM474231 6-[[5-amino-7-(4-fluorophenyl)-8-[imidazo[1,2-a] pyridin-6-yl]-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl] methyl]pyridin-2-amine::US10858365, Compound 37::US11629147, Cmpd. 37

SMILES Nc1cccc(Cc2nc3c(-c4ccc5nccn5c4)c(nc(N)n3n2)-c2ccc(F)cc2)n1

InChI Key InChIKey=OGILCXDJHLQZTN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 474231   

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474231(6-[[5-amino-7-(4-fluorophenyl)-8-[imidazo[1,2-a] p...)
Affinity DataIC50:  6.30nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474231(6-[[5-amino-7-(4-fluorophenyl)-8-[imidazo[1,2-a] p...)
Affinity DataIC50:  4nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474231(6-[[5-amino-7-(4-fluorophenyl)-8-[imidazo[1,2-a] p...)
Affinity DataIC50:  1.80nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474231(6-[[5-amino-7-(4-fluorophenyl)-8-[imidazo[1,2-a] p...)
Affinity DataIC50:  4nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetAdenosine receptor A2a(Mouse)
TBA

US Patent
LigandPNGBDBM474231(6-[[5-amino-7-(4-fluorophenyl)-8-[imidazo[1,2-a] p...)
Affinity DataIC50:  7.30nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474231(6-[[5-amino-7-(4-fluorophenyl)-8-[imidazo[1,2-a] p...)
Affinity DataIC50:  12nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474231(6-[[5-amino-7-(4-fluorophenyl)-8-[imidazo[1,2-a] p...)
Affinity DataIC50:  6.30nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetAdenosine receptor A2b(Human)
TBA

US Patent
LigandPNGBDBM474231(6-[[5-amino-7-(4-fluorophenyl)-8-[imidazo[1,2-a] p...)
Affinity DataIC50:  12nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent