BDBM474478 Example U-16 in WO2008/139161::US10882829, Example 15::US11673870, Example 15

SMILES NC(=O)c1nc(oc1Nc1ccc(cc1)C(=O)NCCO)-c1c(F)cccc1F

InChI Key InChIKey=LELIWIPWPFFQAG-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 474478   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sareum

US Patent
LigandPNGBDBM474478(Example U-16 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 7.5nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sareum

US Patent
LigandPNGBDBM474478(Example U-16 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 7.5nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Sareum

US Patent
LigandPNGBDBM474478(Example U-16 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 41.1nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Sareum

US Patent
LigandPNGBDBM474478(Example U-16 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 41.1nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Sareum

US Patent
LigandPNGBDBM474478(Example U-16 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 101nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Sareum

US Patent
LigandPNGBDBM474478(Example U-16 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 101nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Sareum

US Patent
LigandPNGBDBM474478(Example U-16 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 195nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Sareum

US Patent
LigandPNGBDBM474478(Example U-16 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 195nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent