BDBM474480 Example U-21 in WO2008/139161::US10882829, Example 17::US11673870, Example 17

SMILES NC(=O)c1nc(oc1Nc1ccc(cc1)C(=O)NC1CCNCC1)-c1c(F)cccc1F

InChI Key InChIKey=LOXGJAFFTNHMKC-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 474480   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sareum

US Patent
LigandPNGBDBM474480(Example U-21 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 13.7nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sareum

US Patent
LigandPNGBDBM474480(Example U-21 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 13.7nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Sareum

US Patent
LigandPNGBDBM474480(Example U-21 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 99.2nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Sareum

US Patent
LigandPNGBDBM474480(Example U-21 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 99.2nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Sareum

US Patent
LigandPNGBDBM474480(Example U-21 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 153nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Sareum

US Patent
LigandPNGBDBM474480(Example U-21 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 153nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Sareum

US Patent
LigandPNGBDBM474480(Example U-21 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 167nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Sareum

US Patent
LigandPNGBDBM474480(Example U-21 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50: 167nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent