BDBM474482 2-(2,6-Dichloro-phenyl)-5- (4-methanesulfonyl- phenylamino)-oxazole-4- carboxylic acid amide::US10882829, Example 19::US11673870, Example 19

SMILES CS(=O)(=O)c1ccc(Nc2oc(nc2C(N)=O)-c2c(Cl)cccc2Cl)cc1

InChI Key InChIKey=VSESJZFXWMRDNW-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 474482   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sareum

US Patent
LigandPNGBDBM474482(2-(2,6-Dichloro-phenyl)-5- (4-methanesulfonyl- phe...)
Affinity DataIC50: 2.30nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sareum

US Patent
LigandPNGBDBM474482(2-(2,6-Dichloro-phenyl)-5- (4-methanesulfonyl- phe...)
Affinity DataIC50: 2.30nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Sareum

US Patent
LigandPNGBDBM474482(2-(2,6-Dichloro-phenyl)-5- (4-methanesulfonyl- phe...)
Affinity DataIC50: 21.9nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Sareum

US Patent
LigandPNGBDBM474482(2-(2,6-Dichloro-phenyl)-5- (4-methanesulfonyl- phe...)
Affinity DataIC50: 21.9nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Sareum

US Patent
LigandPNGBDBM474482(2-(2,6-Dichloro-phenyl)-5- (4-methanesulfonyl- phe...)
Affinity DataIC50: 87.7nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Sareum

US Patent
LigandPNGBDBM474482(2-(2,6-Dichloro-phenyl)-5- (4-methanesulfonyl- phe...)
Affinity DataIC50: 87.7nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Sareum

US Patent
LigandPNGBDBM474482(2-(2,6-Dichloro-phenyl)-5- (4-methanesulfonyl- phe...)
Affinity DataIC50: 214nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Sareum

US Patent
LigandPNGBDBM474482(2-(2,6-Dichloro-phenyl)-5- (4-methanesulfonyl- phe...)
Affinity DataIC50: 214nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent