BDBM475685 2- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]pyrimidin-4- yl)- 3,4,4a,5,6,8- hexahydro-1H- 2,7- naphthyridin-2- yl]pyrimidine- 5-carbonitrile::US10851116, Example 7

SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncc(cn1)C#N

InChI Key InChIKey=PBSGRFITHPNSPA-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 475685   

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

US Patent
LigandPNGBDBM475685(2- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  5nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandPNGBDBM475685(2- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  46nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM475685(2- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  140nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM475685(2- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  740nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent