BDBM475686 6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]pyrimidin-4- yl)- 3,4,4a,5,6,8- hexahydro-1H- 2,7- naphthyridin-2- yl]-4-methyl- pyridine-3- carbonitrile::US10851116, Example 8

SMILES Cc1cc(ncc1C#N)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12

InChI Key InChIKey=KIVFAVNSHXCSPW-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 475686   

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

US Patent
LigandPNGBDBM475686(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  21nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandPNGBDBM475686(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  86nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM475686(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  269nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM475686(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  2.11E+3nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent