BDBM475698 2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,4,4a,5,6,8-hexahydro-1H-2,7-naphthyridin-2-yl]-5-bromo-1,3,4-thiadiazole ::US10851116, Example 20

SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1nnc(Br)s1

InChI Key InChIKey=UQPHYRXUELKSJT-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 475698   

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandPNGBDBM475698(2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataEC50:  4nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

US Patent
LigandPNGBDBM475698(2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataEC50:  5nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM475698(2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataEC50:  17nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM475698(2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataEC50:  269nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent