BDBM475713 4-[(3aS*,7aS*)-3a-methyl-2-(5-methylsulfonyl-2-pyridyl)-1,3,4,6,7,7a-hexahydropyrrolo[3,4-c]pyridin-5-yl]-7H-pyrrolo[2,3-d]pyrimidine ::US10851116, Example 35

SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)S(C)(=O)=O

InChI Key InChIKey=RITIYSYJXDLIGD-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 475713   

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandPNGBDBM475713(4-[(3aS*,7aS*)-3a-methyl-2-(5-methylsulfonyl-2-pyr...)
Affinity DataEC50:  13nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

US Patent
LigandPNGBDBM475713(4-[(3aS*,7aS*)-3a-methyl-2-(5-methylsulfonyl-2-pyr...)
Affinity DataEC50:  95nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM475713(4-[(3aS*,7aS*)-3a-methyl-2-(5-methylsulfonyl-2-pyr...)
Affinity DataEC50:  131nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM475713(4-[(3aS*,7aS*)-3a-methyl-2-(5-methylsulfonyl-2-pyr...)
Affinity DataEC50:  2.44E+3nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent