BDBM475924 (4S)-4-[[(2S)-2-[[(2R)-2- (3-chloro-5- cyanophenoxy)-3-(3- chlorophenyl)propanoyl] amino]-2- phenylacetyl]amino]-2,2- difluoro-5-methyl-3-oxo- N-(2,2,2- trifluoroethyl)hexanamide::US10865182, Example 14

SMILES COc1ccc(cc1)[C@H](NC(=O)C(Cc1cccc(c1)C#N)Oc1cc(Cl)cc(c1)C#N)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F

InChI Key InChIKey=OQBVFNUVHHGDOQ-KEKPXRHTSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 475924   

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM475924((4S)-4-[[(2S)-2-[[(2R)-2- (3-chloro-5- cyanophenox...)
Affinity DataIC50:  1.76nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent