BDBM477066 US10882859, Example 1

SMILES CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)N3CCOCC3)C4)n[nH]c2c1

InChI Key InChIKey=DJUAJWMTCKJXRM-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 477066   

TargetTyrosine-protein kinase JAK2(Human)
Topivert Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 477066BDBM477066(US10882859, Example 1)
Affinity DataKd:  0.0520nMAssay Description:The biochemical JAK family enzyme binding assays carried out at DiscoveRx.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Topivert Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 477066BDBM477066(US10882859, Example 1)
Affinity DataKd:  0.0980nMAssay Description:The biochemical JAK family enzyme binding assays carried out at DiscoveRx.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Topivert Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 477066BDBM477066(US10882859, Example 1)
Affinity DataKd:  0.110nMAssay Description:The biochemical JAK family enzyme binding assays carried out at DiscoveRx.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Topivert Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 477066BDBM477066(US10882859, Example 1)
Affinity DataKd:  0.620nMAssay Description:The biochemical JAK family enzyme binding assays carried out at DiscoveRx.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent