BDBM477711 US10889571, Example 52::US20240101536, Example 52

SMILES FC(F)(Cl)Oc1ccc(NC(=O)c2cc(-c3cncnc3)c3n(cnc3c2)C2CCC2)cc1

InChI Key InChIKey=OYKVNLWRAWGKNA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 477711   

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Terns Pharmaceuticals

US Patent
LigandPNGBDBM477711(US10889571, Example 52 | US20240101536, Example 52...)
Affinity DataIC50: 0.370nMAssay Description:ABL1 WT protein (64-515aa) containing an N-terminal His tag was produced by co-expression with YopH in Sf9 insect cells. Cells were harvested by cent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2025
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Terns Pharmaceuticals

US Patent
LigandPNGBDBM477711(US10889571, Example 52 | US20240101536, Example 52...)
Affinity DataIC50: 0.370nMAssay Description:The activity of the enzyme and compound inhibition was tested using an EZ reader microfluidic mobility shift assay (PerkinElmer, Waltham, MA). For in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Terns Pharmaceuticals

US Patent
LigandPNGBDBM477711(US10889571, Example 52 | US20240101536, Example 52...)
Affinity DataIC50: 0.370nMAssay Description:ABL1 WT protein (64-515aa) containing an N-terminal His tag was produced by co-expression with YopH in Sf9 insect cells. Cells were harvested by cent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent