BDBM477967 US10889591, Compound 77::US11434248, Compound 77

SMILES O=c1[nH]c2cnc(cc2c(N2CCC3(CCC3)CC2)c1C#N)C#N

InChI Key InChIKey=QLKNNMBTNMEQPJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 477967   

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Nanjing Transthera Biosciences

US Patent
LigandPNGBDBM477967(US10889591, Compound 77 | US11434248, Compound 77)
Affinity DataIC50: 33nMAssay Description:Test substance: Compounds of the invention, prepared by the corresponding examples of the invention1. Experimental materials and instrumentsPDE9A2 En...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2022
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Nanjing Transthera Biosciences

US Patent
LigandPNGBDBM477967(US10889591, Compound 77 | US11434248, Compound 77)
Affinity DataIC50: 33nMAssay Description:1. Experimental materials and instrumentsPDE9A2 Enzyme (BPS, Cat. No. 60090)384-well plate (Perkin Elmer, Cat. No. 6007279)2. Experimental procedureP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent