BDBM478987 (R)-1-(5-(3-((5-chloro-4- methoxypyrimidin-2- yl)amino)pyrrolidine-1- carbonyl)indolin-1-yl)prop-2-en-1- one::US10894788, Example 27::US10894788, Example 49::US11390618, Example 49

SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc3N(CCc3c2)C(=O)C=C)ncc1Cl

InChI Key InChIKey=BUQHSGLZJNNJCB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 478987   

TargetCyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM478987(US10894788, Example 27 | (R)-1-(5-(3-((5-chloro-4-...)
Affinity DataIC50: 100nMAssay Description:For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM478987(US10894788, Example 27 | (R)-1-(5-(3-((5-chloro-4-...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM478987(US10894788, Example 27 | (R)-1-(5-(3-((5-chloro-4-...)
Affinity DataIC50: 100nMAssay Description:For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM478987(US10894788, Example 27 | (R)-1-(5-(3-((5-chloro-4-...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent