BDBM479059 (R)-N-(4-(3-((5-cyclopropyl-4- methoxypyrimidin-2- yl)amino)pyrrolidine-1- carbonyl)phenyl)acrylamide::US10894788, Example 99::US11390618, Example 99

SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1C1CC1

InChI Key InChIKey=ISIYHJMGMMBACO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 479059   

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 479059BDBM479059((R)-N-(4-(3-((5-cyclopropyl-4- methoxypyrimidin-2-...)
Affinity DataIC50: 550nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 479059BDBM479059((R)-N-(4-(3-((5-cyclopropyl-4- methoxypyrimidin-2-...)
Affinity DataIC50: 550nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
US Patent