BDBM479104 (R)-N-(4-(3-((5-chloro-4- ethoxypyrimidin-2- yl)amino)pyrrolidine-1-carbonyl)-2- (2- (dimethylamino)ethoxy)phenyl) acrylamide::US10894788, Example 144::US11390618, Example 144

SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(OCCN(C)C)c2)ncc1Cl

InChI Key InChIKey=VDQUZELRGNRXJX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 479104   

TargetCyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM479104((R)-N-(4-(3-((5-chloro-4- ethoxypyrimidin-2- yl)am...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM479104((R)-N-(4-(3-((5-chloro-4- ethoxypyrimidin-2- yl)am...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent