BDBM479520 3-amino-6-(2,6-dimethylpyridin-4-yl)- N-(2-methoxybenzyl)-5-(5- methylfuran-2-yl)pyrazine-2-carboxamide::US10898481, Compound 61::US11571420, Compound 61

SMILES COc1ccccc1CNC(=O)c1nc(-c2cc(C)nc(C)c2)c(nc1N)-c1ccc(C)o1

InChI Key InChIKey=BJQRPWQCDUCEJU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 479520   

TargetAdenosine receptor A2a(Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM479520(3-amino-6-(2,6-dimethylpyridin-4-yl)- N-(2-methoxy...)
Affinity DataIC50: 7.90nMAssay Description:Binding affinity and specificalities of the compounds against different subtype of human adenosine receptors (hA1, hA2a, hA2b, and hA3) were characte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent

TargetAdenosine receptor A2a(Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM479520(3-amino-6-(2,6-dimethylpyridin-4-yl)- N-(2-methoxy...)
Affinity DataIC50: 7.90nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM479520(3-amino-6-(2,6-dimethylpyridin-4-yl)- N-(2-methoxy...)
Affinity DataIC50: 52nMAssay Description:Binding affinity and specificalities of the compounds against different subtype of human adenosine receptors (hA1, hA2a, hA2b, and hA3) were characte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM479520(3-amino-6-(2,6-dimethylpyridin-4-yl)- N-(2-methoxy...)
Affinity DataIC50: 52nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent