BDBM479528 3-amino-6-(3-methylimidazo[1,2-a] pyridin-6-yl)-N-((1-methylpyrrolidin-2-yl) methyl)-5-(oxazol-2-yl)pyrazine-2- carboxamide (isomer 1)::US10898481, Compound 120::US10898481, Compound 121::US11571420, Compound 121

SMILES CN1CCCC1CNC(=O)c1nc(-c2ccc3ncc(C)n3c2)c(nc1N)-c1ncco1

InChI Key InChIKey=QLTDCHMTYUDVQH-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 479528   

TargetAdenosine receptor A2a(Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM479528(3-amino-6-(3-methylimidazo[1,2-a] pyridin-6-yl)-N-...)
Affinity DataIC50: 2.90nMAssay Description:Binding affinity and specificalities of the compounds against different subtype of human adenosine receptors (hA1, hA2a, hA2b, and hA3) were characte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent

TargetAdenosine receptor A2a(Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM479528(3-amino-6-(3-methylimidazo[1,2-a] pyridin-6-yl)-N-...)
Affinity DataIC50: 2.90nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetAdenosine receptor A2a(Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM479528(3-amino-6-(3-methylimidazo[1,2-a] pyridin-6-yl)-N-...)
Affinity DataIC50: 3.70nMAssay Description:Binding affinity and specificalities of the compounds against different subtype of human adenosine receptors (hA1, hA2a, hA2b, and hA3) were characte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent

TargetAdenosine receptor A2a(Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM479528(3-amino-6-(3-methylimidazo[1,2-a] pyridin-6-yl)-N-...)
Affinity DataIC50: 3.70nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM479528(3-amino-6-(3-methylimidazo[1,2-a] pyridin-6-yl)-N-...)
Affinity DataIC50: 116nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM479528(3-amino-6-(3-methylimidazo[1,2-a] pyridin-6-yl)-N-...)
Affinity DataIC50: 116nMAssay Description:Binding affinity and specificalities of the compounds against different subtype of human adenosine receptors (hA1, hA2a, hA2b, and hA3) were characte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM479528(3-amino-6-(3-methylimidazo[1,2-a] pyridin-6-yl)-N-...)
Affinity DataIC50: 156nMAssay Description:Binding affinity and specificalities of the compounds against different subtype of human adenosine receptors (hA1, hA2a, hA2b, and hA3) were characte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM479528(3-amino-6-(3-methylimidazo[1,2-a] pyridin-6-yl)-N-...)
Affinity DataIC50: 156nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent