BDBM479533 3-amino-6-(3-methylimidazo[1,2-a] pyridin-6-yl)-5-(oxazol-2-yl)-N-(oxetan-2- ylmethyl)pyrazine-2-carboxamide (isomer 1)::US10898481, Compound 134::US10898481, Compound 135::US11571420, Compound 135

SMILES Cc1cnc2ccc(cn12)-c1nc(C(=O)NCC2CCO2)c(N)nc1-c1ncco1

InChI Key InChIKey=KRMSXKRAKMCMKK-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 479533   

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM479533(US10898481, Compound 134 | US10898481, Compound 13...)
Affinity DataIC50: 2nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM479533(US10898481, Compound 134 | US10898481, Compound 13...)
Affinity DataIC50: 2nMAssay Description:Binding affinity and specificalities of the compounds against different subtype of human adenosine receptors (hA1, hA2a, hA2b, and hA3) were characte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM479533(US10898481, Compound 134 | US10898481, Compound 13...)
Affinity DataIC50: 5.5nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM479533(US10898481, Compound 134 | US10898481, Compound 13...)
Affinity DataIC50: 5.5nMAssay Description:Binding affinity and specificalities of the compounds against different subtype of human adenosine receptors (hA1, hA2a, hA2b, and hA3) were characte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM479533(US10898481, Compound 134 | US10898481, Compound 13...)
Affinity DataIC50: 161nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM479533(US10898481, Compound 134 | US10898481, Compound 13...)
Affinity DataIC50: 161nMAssay Description:Binding affinity and specificalities of the compounds against different subtype of human adenosine receptors (hA1, hA2a, hA2b, and hA3) were characte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM479533(US10898481, Compound 134 | US10898481, Compound 13...)
Affinity DataIC50: 216nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM479533(US10898481, Compound 134 | US10898481, Compound 13...)
Affinity DataIC50: 216nMAssay Description:Binding affinity and specificalities of the compounds against different subtype of human adenosine receptors (hA1, hA2a, hA2b, and hA3) were characte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent