BDBM480503 US10626113, Compound N::US10899756, Compound V

SMILES COc1ccc(cc1Cl)C(C)Nc1c2CN(CCc2nc2ccc(cc12)C#N)C(C)=O

InChI Key InChIKey=ZJEMKZMTQHUENK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 480503   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Columbia University

US Patent
LigandPNGBDBM480503(US10899756, Compound V | US10626113, Compound N)
Affinity DataIC50: 26.9nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Columbia University

US Patent
LigandPNGBDBM480503(US10899756, Compound V | US10626113, Compound N)
Affinity DataIC50: 26.9nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent